Pdf understanding dental caries from pathogenesis to. Genetic and peripheral factors lead to variations in the oral microbiome. In an introductory section, this white paper looks at the evolution of caries treatment approaches and, because dental caries does not sit in isolation, looks into comorbidities and common risk factors that are shared with other major noncommunicable diseases ncds. Pathobiology of dental caries dental caries is a microbiologic disease that results in the dissolution of the mineral structure of teeth. This book thoroughly explains the biological background of dental caries and the formation of carious lesions, providing the reader with a sound basis for understanding the role and effectiveness of different therapeutic and preventive measures. Dental caries is caused by plaques, which are a community of microorganisms in biofilm format. Get a printable copy pdf file of the complete article 598k, or click on a page image below to browse page by page. Dental caries and periodontitis are among the most common medical conditions. White paper on dental caries prevention and management. Genomewide analysis of dental caries and periodontitis. In vitro experiments showed that acid played no part in the process, the original lesion being formed by a dissolution of the organic material by a mixed culture of strict anaerobes in an alkaline medium.
Understanding dental caries from pathogenesis to prevention and therapy. Our current understanding of the microorganisms involved in the initiation and progression of caries is still rather incomplete. Pathogenesis of dental caries slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Etiology theories of dental caries, factors affecting and pathogenesis of dental caries and stages of caries. Carious lesion dynamics are dependent predominantly on the availability of fermentable sugars, other environmental conditions, bacteria, and host factors. It is the destruction of dental hard acellular tissue by acidic byproducts from the bacterial fermentation of dietary carbohydrates especially sucrose. The caries lesion, the most commonly observed sign of dental caries disease, is the cumulative result of an imbalance in the dynamic demineralization and remineralization process that causes a net mineral loss over time. Full text full text is available as a scanned copy of the original print version. It has known that, in commensalism and coexistence between microorganisms and the host, homeostasis in the oral microbiome is preserved.